PVR

Across TCGA pan-cancer cohorts, PVR RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated PVR data layer compared with 7 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher PVR RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PVR expression acts as an unfavorable survival marker, although some lineages such as PAAD and SCLC show a favorable association.

KIRP, HNSC, and BLCA are the cancer types where PVR RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	III,IV	0.223	0.722	<.001	121	view →
HNSC	DFS	Median	All	0.639	0.748	<.001	120	view →
BLCA	OS	Median	All	0.349	0.502	<.001	116	view →
MESO	OS	Median	All	0.417	0.662	<.001	104	view →
BRCA	DFS	Median	All	0.871	0.931	<.001	102	view →
CESC	OS	Median	All	0.728	0.873	<.001	76	view →
ACC	OS	Tertile	All	0.294	0.882	<.001	55	view →
LUAD	DFS	Median	All	0.586	0.733	<.001	48	view →
UVM	DFS	Tertile	III,IV	0.242	1.000	.004	44	view →
LGG	OS	Median	All	0.745	0.879	<.001	43	view →
UCS	DFS	Quartile	II,III,IV	0.229	0.605	.005	34	view →
LUSC	DFS	Tertile	III,IV	0.547	0.794	.004	31	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

PVR–KIRP (OS)

Open the KIRP breakdown →