PVR

Across TCGA patient cohorts, PVR mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PVR-associated genes across cancer lineages are A-Raf_pS299, JNK2, and Ku80. Each is linked with PVR in more than 1 cancer types. Because this analysis shows association rather than direction, both PVR-to-partner and partner-to-PVR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by PVR-low versus PVR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PVR→partner) and Y-score (partner→PVR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.123	-3.000	.022	.036	3	1
UCEC	JNK2 →	+0.260	+3.179	.003	.010	3	1
UCEC	Ku80 →	+0.335	+2.713	.001	.003	3	1
UCEC	MEK1 →	+0.502	+3.584	.002	.002	3	1
UCEC	Notch1 →	+0.188	+2.331	.003	.019	3	1
UCEC	N-Ras →	-0.115	-1.986	.031	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

A-Raf_pS299 by PVR expression — UCEC

Explore this box plot interactively →