PVR

Across TCGA cell cohorts, PVR mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PVR-associated genes across cancer lineages are SRY, OR10T2, and OR10R2. Each is linked with PVR in more than 1 cancer types. Because this analysis shows association rather than direction, both PVR-to-partner and partner-to-PVR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SRY grouped by PVR-low versus PVR-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PVR→partner) and Y-score (partner→PVR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SRY →	+0.029	+4.874	<.001	.002	3	1
BLOOD_Leukemia	OR10T2 →	+0.707	+4.276	<.001	.007	3	1
BLOOD_Leukemia	OR10R2 →	+2.034	+4.551	<.001	.004	3	1
BLOOD_Leukemia	PLA2G4D →	+0.042	+4.254	.006	.007	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

SRY by PVR expression — BLOOD_Leukemia

Explore this box plot interactively →