Across TCGA patient cohorts, PVALEF mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PVALEF-associated genes across cancer lineages are MIR6783, MIR8071-1, and MIR4706. Each is linked with PVALEF in more than 1 cancer types. Because this analysis shows association rather than direction, both PVALEF-to-partner and partner-to-PVALEF results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PVALEF→partner) and Y-score (partner→PVALEF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6783 →	+0.818	+3.517	.001	.005	3	1
UCEC	MIR8071-1 →	+1.942	+3.799	<.001	.005	3	1
UCEC	MIR4706 →	+0.510	+3.648	.009	.004	3	1
UCEC	OR4C6 →	+0.161	+3.538	.003	.005	3	1
UCEC	OR13D3P →	+0.214	+4.315	<.001	.001	3	1
UCEC	RNU6-1284P →	+0.485	+4.186	.005	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Exploration

PVALEF survival (RNA) · tumor vs normal (RNA) · all PVALEF data types