PUM3

Across TCGA cell cohorts, PUM3 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PUM3-associated genes across cancer lineages are VN1R2, ZNF831, and CENPVL1. Each is linked with PUM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PUM3-to-partner and partner-to-PUM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VN1R2 grouped by PUM3-low versus PUM3-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PUM3→partner) and Y-score (partner→PUM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	VN1R2 →	+0.009	+4.643	<.001	.005	3	1
LARGE_INTESTINE	ZNF831 →	+0.013	+3.688	<.001	.002	3	1
LARGE_INTESTINE	CENPVL1 →	+0.150	+3.510	<.001	.003	3	1
BLOOD_Leukemia	SLC5A7 →	+0.006	+4.922	<.001	.009	3	1
BLOOD_Leukemia	USP29 →	+0.006	+4.922	<.001	.009	3	1
BLOOD_Leukemia	LALBA →	+0.021	+4.922	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

VN1R2 by PUM3 expression — BLOOD_Lymphoma

Explore this box plot interactively →