PUM3

Across TCGA pan-cancer cohorts, PUM3 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PUM3’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PUM3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PUM3 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

COAD, BLCA, and LIHC are the cancer types where PUM3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PUM3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	+1.365	<.001	11	view →
BLCA	All	III,IV	+0.695	<.001	10	view →
LIHC	Male	II,III,IV	+1.228	<.001	9	view →
STAD	Male	II,III,IV	+0.923	<.001	9	view →
HNSC	Male	All	+0.681	<.001	8	view →
READ	All	All	+1.165	<.001	7	view →
LUAD	Male	All	+0.556	<.001	7	view →
CHOL	Male	All	+2.324	<.001	5	view →
LUSC	Male	II,III,IV	+0.683	<.001	5	view →
KIRC	All	All	+0.316	<.001	5	view →
KIRP	All	II,III,IV	+0.526	.024	4	view →
THCA	All	All	−0.181	.005	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PUM3–COAD

Open the COAD breakdown →