PTPRVP

Across TCGA patient cohorts, PTPRVP mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPRVP-associated genes across cancer lineages are eIF4E, eIF4G, and A-Raf_pS299. Each is linked with PTPRVP in more than 1 cancer types. Because this analysis shows association rather than direction, both PTPRVP-to-partner and partner-to-PTPRVP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by PTPRVP-low versus PTPRVP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRVP→partner) and Y-score (partner→PTPRVP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.205	+2.584	.011	.001	3	1
UCEC	eIF4G →	+0.272	+1.678	.022	.023	3	1
UCEC	A-Raf_pS299 →	-0.123	-2.584	.007	.010	3	1
UCEC	ERK2 →	+0.204	+2.459	.005	.019	3	1
UCEC	FASN →	+0.324	+1.678	.032	.023	3	1
UCEC	FOXO3a_pS318_S321 →	-0.152	-2.405	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

eIF4E by PTPRVP expression — UCEC

Explore this box plot interactively →