PTPRU

Across TCGA patient cohorts, PTPRU mutation is significantly associated with the RNA expression of many other genes, with 8,091 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPRU-associated genes across cancer lineages are SHROOM4, DCK, and ENO1. Each is linked with PTPRU in more than 4 cancer types. Because this analysis shows association rather than direction, both PTPRU-to-partner and partner-to-PTPRU results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SHROOM4 grouped by PTPRU-low versus PTPRU-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRU→partner) and Y-score (partner→PTPRU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SHROOM4 →	-0.842	-2.558	<.001	.001	3	5
UCEC	DCK →	+0.704	+2.233	<.001	<.001	3	5
STAD	ENO1 →	+0.565	+2.610	.002	.005	3	5
UCEC	NDC80 →	+0.446	+2.425	.007	.001	3	5
UCEC	WDR76 →	+0.865	+2.057	<.001	<.001	3	5
LUAD	RPF1 →	+0.527	+3.596	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,091 associations by consensus.

SHROOM4 by PTPRU expression — COAD

Explore this box plot interactively →