PTPRU

Across TCGA pan-cancer cohorts, PTPRU RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated PTPRU data layer compared with 10 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher PTPRU RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PTPRU expression acts as an unfavorable survival marker, although some lineages such as ACC and THYM show a favorable association.

OV, PAAD, and COAD are the cancer types where PTPRU RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Quartile	III,IV	0.775	0.894	.003	46	view →
PAAD	OS	Tertile	All	0.325	0.543	.002	39	view →
COAD	DFS	Median	All	0.398	0.709	<.001	36	view →
READ	DFS	Quartile	All	0.323	0.842	.001	36	view →
LUSC	OS	Median	All	0.606	0.737	<.001	36	view →
ACC	OS	Median	All	0.936	0.805	.008	35	view →
THYM	DFS	Tertile	II,III,IV	1.000	0.604	.001	33	view →
HNSC	OS	Median	All	0.274	0.506	.002	21	view →
KIRP	DFS	Median	IV	0.036	0.528	.001	18	view →
MESO	OS	Median	All	0.471	0.299	.010	14	view →
GBM	OS	Tertile	All	0.194	0.334	.011	9	view →
DLBC	OS	Tertile	IV	1.000	0.362	.018	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

PTPRU–OV (OS)

Open the OV breakdown →