PTPRU

Across TCGA pan-cancer cohorts, PTPRU RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PTPRU’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PTPRU RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PTPRU is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

COAD, KIRC, and THCA are the cancer types where PTPRU tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PTPRU RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+1.209	<.001	10	view →
KIRC	Male	All	+1.037	<.001	10	view →
THCA	Male	All	+1.064	<.001	8	view →
KICH	All	All	−1.066	<.001	6	view →
LUSC	All	All	−0.697	<.001	5	view →
CHOL	All	II,III,IV	+2.275	<.001	4	view →
STAD	Male	All	+1.736	<.001	4	view →
KIRP	All	II,III,IV	+1.256	.008	4	view →
BLCA	All	III,IV	+1.339	.018	3	view →
LIHC	Female	All	+1.122	<.001	3	view →
LUAD	All	IV	−2.070	.021	2	view →
PRAD	All	All	−0.579	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PTPRU–COAD

Open the COAD breakdown →