PTPRU

Across TCGA patient cohorts, PTPRU mutation is significantly associated with the total protein of many other genes, with 87 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPRU-associated genes across cancer lineages are 4E-BP1, Cyclin-B1, and TFRC. Each is linked with PTPRU in more than 4 cancer types. Because this analysis shows association rather than direction, both PTPRU-to-partner and partner-to-PTPRU results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by PTPRU-low versus PTPRU-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRU→partner) and Y-score (partner→PTPRU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	4E-BP1 →	+0.329	+2.321	.020	.035	3	5
UCEC	Cyclin-B1 →	+0.586	+3.247	<.001	<.001	3	4
UCEC	TFRC →	+0.460	+1.999	.001	.002	3	4
STAD	eIF4G →	+0.540	+3.321	.011	.009	3	3
STAD	FoxM1 →	+0.403	+3.490	<.001	.002	3	3
STAD	Rictor_pT1135 →	-0.177	-2.000	.004	.030	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 87 associations by consensus.

4E-BP1 by PTPRU expression — LUAD

Explore this box plot interactively →