PTPRU

Across TCGA cell cohorts, PTPRU mutation is significantly associated with the RNA expression of many other genes, with 272 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTPRU-associated genes across cancer lineages are CEACAM4, AVP, and LRRC3C. Each is linked with PTPRU in more than 1 cancer types. Because this analysis shows association rather than direction, both PTPRU-to-partner and partner-to-PTPRU results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CEACAM4 grouped by PTPRU-low versus PTPRU-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRU→partner) and Y-score (partner→PTPRU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CEACAM4 →	+0.038	+4.237	<.001	.006	3	2
BLOOD_Lymphoma	AVP →	+0.016	+3.209	<.001	.004	3	2
BLOOD_Lymphoma	LRRC3C →	+0.065	+3.296	.009	.009	3	2
LARGE_INTESTINE	GNMT →	+0.163	+1.524	.004	.008	3	2
LARGE_INTESTINE	WRAP53 →	+0.426	+2.000	.006	.009	3	2
LARGE_INTESTINE	ITGA10 →	+0.341	+2.115	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 272 associations by consensus.

CEACAM4 by PTPRU expression — PANCREAS

Explore this box plot interactively →