PTPRS

Across TCGA patient cohorts, PTPRS protein abundance is significantly associated with the protein abundance of many other proteins, with 32,144 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PTPRS-associated proteins across cancer lineages are PALM, HSPA12B, and NRDC. Each is linked with PTPRS in more than 7 cancer types. Because this analysis shows association rather than direction, both PTPRS-to-partner and partner-to-PTPRS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PTPRS versus PALM in GBM, with a Pearson correlation of 0.75.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRS→partner) and Y-score (partner→PTPRS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PALM →	+0.737	+0.513	<.001	<.001	3	8
BRCA	HSPA12B →	+0.506	+0.470	.001	<.001	3	7
HNSC	NRDC →	-0.313	-0.398	<.001	<.001	3	7
BRCA	CNOT1 →	-0.162	-0.363	<.001	<.001	3	7
LSCC	PTN →	+0.715	+0.340	<.001	<.001	3	6
BRCA	NUP205 →	-0.245	-0.340	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 32,144 associations by consensus.

PTPRS vs PALM — GBM

Explore this scatter interactively →