PTPRS

Across TCGA pan-cancer cohorts, PTPRS RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated PTPRS data layer compared with 8 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PTPRS RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated PTPRS expression acts as an unfavorable survival marker, although some lineages such as HNSC and PAAD show a favorable association.

HNSC, ACC, and KIRP are the cancer types where PTPRS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.763	0.619	.001	101	view →
ACC	DFS	Median	All	0.380	0.773	<.001	88	view →
KIRP	DFS	Tertile	All	0.759	0.933	<.001	57	view →
PAAD	DFS	Median	All	0.382	0.202	.001	43	view →
CESC	OS	Tertile	III,IV	0.771	0.479	.010	32	view →
SKCM	OS	Tertile	III,IV	0.273	0.684	<.001	17	view →
ESCA	OS	Quartile	II,III,IV	0.811	0.562	.012	16	view →
CHOL	DFS	Median	III,IV	0.127	0.647	.006	10	view →
LUAD	DFS	Quartile	IV	0.462	1.000	.014	10	view →
LGG	OS	Quartile	All	0.940	0.790	.003	8	view →
BRCA	DFS	Quartile	IV	0.889	0.338	.009	8	view →
MESO	DFS	Median	All	0.302	0.423	.034	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

PTPRS–HNSC (DFS)

Open the HNSC breakdown →