PTPRQ

Across TCGA cell cohorts, PTPRQ mutation is significantly associated with the mutation status of many other genes, with 4,177 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTPRQ-associated genes across cancer lineages are FAM193A, LCT, and ELFN1. Each is linked with PTPRQ in more than 4 cancer types. Because this analysis shows association rather than direction, both PTPRQ-to-partner and partner-to-PTPRQ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM193A grouped by PTPRQ-low versus PTPRQ-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRQ→partner) and Y-score (partner→PTPRQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	FAM193A →	+3.389	+3.389	.001	.001	1	5
SOFT_TISSUE	LCT →	+4.192	+3.852	<.001	<.001	1	5
BLOOD_Lymphoma	ELFN1 →	+4.584	+4.584	.007	.007	1	5
BLOOD_Leukemia	UNC5D →	+4.000	+5.050	.008	.008	1	5
STOMACH	USP34 →	+2.415	+3.807	.006	.006	1	5
LARGE_INTESTINE	SRGAP3 →	+2.182	+2.754	<.001	<.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,177 associations by consensus.

FAM193A by PTPRQ expression — BREAST

Explore this box plot interactively →