PTPRQ

Across TCGA pan-cancer cohorts, PTPRQ RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated PTPRQ data layer compared with 5 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher PTPRQ RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PTPRQ expression acts as an unfavorable survival marker, although some lineages such as LUAD and SKCM show a favorable association.

KIRP, KIRC, and LUAD are the cancer types where PTPRQ RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	All	0.474	0.793	<.001	91	view →
KIRC	DFS	Median	All	0.556	0.681	<.001	70	view →
LUAD	OS	Quartile	All	0.746	0.602	.003	28	view →
BLCA	OS	Median	III,IV	0.462	0.667	.018	20	view →
KICH	OS	Tertile	III,IV	0.178	0.847	<.001	18	view →
SKCM	OS	Tertile	III,IV	0.793	0.610	.008	18	view →
LGG	DFS	Quartile	All	0.725	0.867	<.001	16	view →
CHOL	DFS	Quartile	II,III,IV	1.000	0.211	.008	15	view →
LIHC	OS	Quartile	All	0.670	0.819	.011	11	view →
UCS	DFS	Tertile	II,III,IV	0.695	0.323	.024	8	view →
STAD	OS	Median	All	0.523	0.633	.020	7	view →
UVM	OS	Tertile	All	0.681	0.953	.017	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

PTPRQ–KIRP (OS)

Open the KIRP breakdown →