PTPRH

Across TCGA patient cohorts, PTPRH mutation is significantly associated with the RNA expression of many other genes, with 3,850 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPRH-associated genes across cancer lineages are PSMB6, C17orf98, and MIR6783. Each is linked with PTPRH in more than 3 cancer types. Because this analysis shows association rather than direction, both PTPRH-to-partner and partner-to-PTPRH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMB6 grouped by PTPRH-low versus PTPRH-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPRH→partner) and Y-score (partner→PTPRH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PSMB6 →	+0.321	+2.035	.009	.005	3	4
UCEC	C17orf98 →	+0.240	+1.407	.004	.008	3	3
SKCM	MIR6783 →	+0.268	+1.464	<.001	.004	3	3
BRCA	HMGN2P11 →	+0.165	+4.300	<.001	<.001	3	3
LIHC	RN7SL304P →	+0.123	+5.008	<.001	.004	3	3
LGG	RN7SL134P →	+0.141	+4.013	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,850 associations by consensus.

PSMB6 by PTPRH expression — LUAD

Explore this box plot interactively →