PTPRH

Across TCGA pan-cancer cohorts, PTPRH RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PTPRH’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where PTPRH RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PTPRH is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

LUAD, COAD, and KIRP are the cancer types where PTPRH tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PTPRH RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	III,IV	+4.068	<.001	11	view →
COAD	Female	III,IV	−2.173	<.001	11	view →
KIRP	All	II,III,IV	+1.723	<.001	11	view →
LUSC	Female	All	+2.262	<.001	8	view →
KIRC	Male	All	+0.670	.001	8	view →
HNSC	Male	All	+1.356	<.001	6	view →
READ	All	All	−2.292	<.001	5	view →
STAD	All	All	+1.602	.004	4	view →
PAAD	All	All	+1.545	.002	4	view →
BRCA	All	All	−0.241	.002	4	view →
UCEC	All	IV	+0.704	.022	2	view →
KICH	Female	All	−0.440	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PTPRH–LUAD

Open the LUAD breakdown →