PTPN23

Across TCGA cell cohorts, PTPN23 mutation is significantly associated with the RNA expression of many other genes, with 925 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTPN23-associated genes across cancer lineages are UCMA, LRIT1, and LRIT2. Each is linked with PTPN23 in more than 2 cancer types. Because this analysis shows association rather than direction, both PTPN23-to-partner and partner-to-PTPN23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UCMA grouped by PTPN23-low versus PTPN23-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN23→partner) and Y-score (partner→PTPN23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	UCMA →	+0.044	+1.797	<.001	.009	3	3
CNS	LRIT1 →	+0.545	+2.874	<.001	.003	3	2
CNS	LRIT2 →	+0.399	+2.662	<.001	.005	3	2
LARGE_INTESTINE	FAM149A →	+1.429	+2.628	<.001	.002	3	2
BLOOD_Leukemia	C12orf57 →	+1.112	+2.730	<.001	.001	3	2
BLOOD_Leukemia	GCH1 →	+1.287	+3.321	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 925 associations by consensus.

UCMA by PTPN23 expression — BLOOD_Leukemia

Explore this box plot interactively →