PTPN23

Across TCGA pan-cancer cohorts, PTPN23 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of PTPN23’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PTPN23 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PTPN23 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

COAD, LIHC, and STAD are the cancer types where PTPN23 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PTPN23 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	III,IV	+0.570	<.001	10	view →
LIHC	Male	II,III,IV	+1.244	<.001	9	view →
STAD	Male	II,III,IV	+1.062	<.001	9	view →
KIRC	Male	II,III,IV	−0.546	<.001	6	view →
BLCA	All	All	+0.394	.009	6	view →
BRCA	All	II,III,IV	+0.196	.004	6	view →
HNSC	All	All	+0.345	.001	4	view →
CHOL	Male	All	+1.843	<.001	3	view →
PRAD	All	All	+0.204	.037	2	view →
THCA	All	II,III,IV	−0.275	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

PTPN23–COAD

Open the COAD breakdown →