PTPN18

Across TCGA cell cohorts, PTPN18 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTPN18-associated genes across cancer lineages are ATP1B4, OR4F6, and C14orf180. Each is linked with PTPN18 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTPN18-to-partner and partner-to-PTPN18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATP1B4 grouped by PTPN18-low versus PTPN18-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN18→partner) and Y-score (partner→PTPN18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ATP1B4 →	+0.082	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	OR4F6 →	+0.019	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	C14orf180 →	+0.015	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	OR6N2 →	+0.013	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	OR2A5 →	+0.034	+5.209	.001	.005	3	1
BLOOD_Lymphoma	OR2A12 →	+0.035	+4.867	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

ATP1B4 by PTPN18 expression — BLOOD_Lymphoma

Explore this box plot interactively →