Q-omics provides the consensus-scored OR2A12 profile across patient tissues and cancer cell-line models. OR2A12 expression is associated with patient survival in 14 of 34 cancer types, with the highest sampling consensus in SKCM. Among the 18 cancer types available for tumor–normal comparison, OR2A12 is differentially expressed in 1, with the highest sampling consensus in THCA. Additionally, OR2A12 RNA expression shows 5,407 significant gene co-expression associations, with the highest sampling consensus in KIRP. Together, these results highlight SKCM, THCA, and KIRP as cancer lineages where OR2A12 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for OR2A12 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes OR2A12 survival associations across molecular data types. OR2A12 RNA expression shows survival associations in the most cancer types (14), followed by mutation status (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible OR2A12 RNA expression–survival associations across cancer types. High OR2A12 expression shows unfavorable associations in SKCM, OV, ACC, BLCA, GBM and UCEC. The SKCM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify SKCM as the clearest survival context for OR2A12 RNA expression.
This table summarizes OR2A12 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 1. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for OR2A12. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. OR2A12 shows lower tumor expression in THCA. The THCA box plot shows higher OR2A12 RNA expression in normal versus tumor tissue (log2 FC = −0.017, t-test p = .012).
This table shows molecular features associated with OR2A12 in patient tissues and cancer cell lines. In patient samples, OR2A12 shows the broadest associations at the RNA and protein expression levels, with KIRP recurring as the lineage with the largest associated feature set. In cancer cell lines, OR2A12 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BREAST, while CRISPR and shRNA rows add functional-dependency signals in SKIN and LUNG_NSCLC_LUAD.
