Across TCGA pan-cancer cohorts, OR2A12 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of OR2A12’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where OR2A12 RNA is repressed in tumor relative to normal tissue. In most cancer types OR2A12 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
THCA are the cancer types where OR2A12 tumor–normal differential expression is most reproducible.