PTPN14

Across TCGA patient cohorts, PTPN14 protein abundance is significantly associated with the RNA expression of many other genes, with 9,761 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PTPN14-associated genes across cancer lineages are BICC1, RBMS1, and WWTR1. Each is linked with PTPN14 in more than 5 cancer types. Because this analysis shows association rather than direction, both PTPN14-to-partner and partner-to-PTPN14 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PTPN14 versus BICC1 in LSCC, with a Pearson correlation of 0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN14→partner) and Y-score (partner→PTPN14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	BICC1 →	+0.786	+0.342	<.001	<.001	3	6
BRCA	RBMS1 →	+0.680	+0.423	<.001	<.001	3	5
BRCA	WWTR1 →	+0.684	+0.314	<.001	<.001	3	5
BRCA	SRPX →	+0.887	+0.385	.003	.001	3	5
UCEC	MEIS3 →	+0.943	+0.218	<.001	.003	3	5
LUAD	CAV2 →	+0.887	+0.240	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,761 associations by consensus.

PTPN14 vs BICC1 — LSCC

Explore this scatter interactively →