PTPN14

Across TCGA pan-cancer cohorts, PTPN14 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated PTPN14 data layer compared with 11 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher PTPN14 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PTPN14 expression acts as an unfavorable survival marker, although some lineages such as KIRC and LAML show a favorable association.

ACC, KIRC, and BLCA are the cancer types where PTPN14 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.168	0.701	<.001	108	view →
KIRC	DFS	Tertile	All	0.712	0.487	<.001	80	view →
BLCA	OS	Tertile	II,III,IV	0.511	0.677	.002	59	view →
LGG	OS	Median	All	0.745	0.885	<.001	54	view →
PAAD	OS	Quartile	All	0.232	0.581	<.001	39	view →
MESO	DFS	Median	All	0.242	0.605	.007	36	view →
COAD	OS	Median	All	0.445	0.777	.011	32	view →
STAD	OS	Tertile	All	0.409	0.670	.003	27	view →
HNSC	OS	Tertile	All	0.303	0.654	<.001	22	view →
LAML	DFS	Median	All	0.482	0.281	.013	20	view →
CESC	DFS	Median	III,IV	0.245	0.739	.014	14	view →
SKCM	DFS	Median	III,IV	0.400	0.696	.002	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

PTPN14–ACC (DFS)

Open the ACC breakdown →