PTPN14

Across TCGA pan-cancer cohorts, PTPN14 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PTPN14’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PTPN14 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PTPN14 is over-expressed in tumor, although a few such as BRCA and KICH show the opposite, repressed pattern.

HNSC, LIHC, and BRCA are the cancer types where PTPN14 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PTPN14 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	II,III,IV	+1.098	<.001	12	view →
LIHC	Female	II,III,IV	+1.183	<.001	8	view →
BRCA	All	III,IV	−1.734	<.001	6	view →
KICH	Female	All	−1.641	<.001	6	view →
LUAD	Female	All	−0.617	<.001	5	view →
BLCA	Male	All	−0.822	.011	4	view →
LUSC	All	All	+0.438	.003	4	view →
CHOL	All	All	+3.041	<.001	3	view →
UCEC	All	All	−0.925	<.001	2	view →
STAD	Female	All	−0.842	.046	2	view →
KIRP	Male	All	−0.628	.004	2	view →
PRAD	All	All	−0.444	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PTPN14–HNSC

Open the HNSC breakdown →