PTPN14

Across TCGA patient cohorts, PTPN14 mutation is significantly associated with the RNA expression of many other genes, with 7,224 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPN14-associated genes across cancer lineages are RAB35, LRRC42, and INCENP. Each is linked with PTPN14 in more than 3 cancer types. Because this analysis shows association rather than direction, both PTPN14-to-partner and partner-to-PTPN14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAB35 grouped by PTPN14-low versus PTPN14-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN14→partner) and Y-score (partner→PTPN14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	RAB35 →	+0.490	+3.195	.002	.009	3	4
STAD	LRRC42 →	+0.517	+3.334	.002	.005	3	4
STAD	INCENP →	+0.791	+3.186	<.001	.009	3	4
COAD	SERP2 →	-0.908	-2.797	<.001	.003	3	4
COAD	SKA1 →	+0.835	+2.598	<.001	<.001	3	4
UCEC	LRR1 →	+0.532	+1.691	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,224 associations by consensus.

RAB35 by PTPN14 expression — STAD

Explore this box plot interactively →