PTPN14

Across TCGA cell cohorts, PTPN14 mutation is significantly associated with the RNA expression of many other genes, with 689 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTPN14-associated genes across cancer lineages are PROP1, ZNF648, and IFT27. Each is linked with PTPN14 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTPN14-to-partner and partner-to-PTPN14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PROP1 grouped by PTPN14-low versus PTPN14-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN14→partner) and Y-score (partner→PTPN14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PROP1 →	+0.009	+3.867	<.001	.002	3	2
BLOOD_Lymphoma	ZNF648 →	+0.131	+3.669	.003	.006	3	2
LARGE_INTESTINE	IFT27 →	+0.752	+3.451	.008	.002	3	2
LARGE_INTESTINE	GFRA4 →	+0.012	+2.538	.006	.005	3	2
BREAST	C1orf146 →	+0.030	+4.963	<.001	.001	3	2
URINARY_TRACT	CLLU1-AS1 →	+0.113	+5.087	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 689 associations by consensus.

PROP1 by PTPN14 expression — BLOOD_Lymphoma

Explore this box plot interactively →