Across TCGA patient cohorts, PTPN1 protein abundance is significantly associated with the RNA expression of many other genes, with 16,254 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible PTPN1-associated genes across cancer lineages are DOK3, MTURN, and MAGI1. Each is linked with PTPN1 in more than 6 cancer types. Because this analysis shows association rather than direction, both PTPN1-to-partner and partner-to-PTPN1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN1→partner) and Y-score (partner→PTPN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	DOK3 →	+0.688	+0.262	.005	.005	3	7
GBM	MTURN →	-1.164	-0.264	<.001	<.001	3	7
CCRCC	MAGI1 →	-0.812	-0.423	<.001	<.001	3	7
BRCA	GPRASP2 →	-0.830	-0.505	<.001	<.001	3	7
CCRCC	GPRASP1 →	-0.863	-0.535	<.001	<.001	3	7
OV	BMPR1A →	-0.587	-0.292	.007	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,254 associations by consensus.

Exploration

PTPN1 survival (RNA) · tumor vs normal (RNA) · all PTPN1 data types