Across TCGA patient cohorts, PTPN1 mutation is significantly associated with the RNA expression of many other genes, with 3,213 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTPN1-associated genes across cancer lineages are MAGEB10, MIR3925, and COPS8P1. Each is linked with PTPN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTPN1-to-partner and partner-to-PTPN1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTPN1→partner) and Y-score (partner→PTPN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MAGEB10 →	+0.126	+4.653	<.001	.004	3	2
LUAD	MIR3925 →	+0.523	+5.888	<.001	.002	3	2
UCEC	COPS8P1 →	+0.065	+1.801	.001	.007	3	2
CESC	LINC02559 →	+1.329	+5.342	<.001	.002	3	2
CESC	TSPAN9-IT1 →	+0.115	+4.653	<.001	.004	3	2
UCEC	RN7SL134P →	+0.104	+2.236	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,213 associations by consensus.

Exploration

PTPN1 survival (RNA) · tumor vs normal (RNA) · all PTPN1 data types