PTH2R

Across TCGA patient cohorts, PTH2R mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTH2R-associated genes across cancer lineages are p62 Lck ligand, Notch1, and PDCD4. Each is linked with PTH2R in more than 1 cancer types. Because this analysis shows association rather than direction, both PTH2R-to-partner and partner-to-PTH2R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by PTH2R-low versus PTH2R-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTH2R→partner) and Y-score (partner→PTH2R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	p62 Lck ligand →	+0.497	+3.186	.037	.010	3	2
COAD	Notch1 →	+0.230	+3.008	.016	.019	3	2
UCEC	PDCD4 →	-0.439	-1.765	.012	.014	3	2
UCEC	Annexin-1 →	+0.560	+3.604	.004	.001	3	2
UCEC	S6_pS240_S244 →	+0.372	+1.415	.014	.046	3	2
UCEC	C-Raf →	+0.153	+1.415	.004	.046	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

p62 Lck ligand by PTH2R expression — LUAD

Explore this box plot interactively →