PTH2R

Across TCGA pan-cancer cohorts, PTH2R RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of PTH2R’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where PTH2R RNA is repressed in tumor relative to normal tissue. In most cancer types PTH2R is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

KICH, HNSC, and BRCA are the cancer types where PTH2R tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PTH2R RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−3.915	<.001	11	view →
HNSC	All	All	+0.654	.003	8	view →
BRCA	All	III,IV	−0.973	<.001	6	view →
LUSC	Male	All	+1.196	<.001	5	view →
LIHC	Male	All	+1.508	<.001	4	view →
STAD	All	II,III,IV	+0.923	.005	4	view →
READ	Male	All	−0.100	.022	3	view →
UCEC	All	IV	+3.445	.001	2	view →
BLCA	All	All	+0.850	.040	2	view →
CHOL	All	All	+1.268	.029	1	view →
LIHC	Female	III,IV	−0.102	.022	1	view →
COAD	All	IV	−0.082	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 11 lineages.

PTH2R–KICH

Open the KICH breakdown →