PTH2R

Across TCGA pan-cancer cohorts, PTH2R RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated PTH2R data layer compared with 5 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher PTH2R RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PTH2R expression acts as an unfavorable survival marker, although some lineages such as THCA and KIRC show a favorable association.

UVM, ACC, and THCA are the cancer types where PTH2R RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.307	0.631	<.001	87	view →
ACC	OS	Median	All	0.437	0.795	<.001	70	view →
THCA	DFS	Median	IV	0.910	0.430	<.001	53	view →
KIRC	OS	Median	All	0.692	0.570	.001	42	view →
SKCM	DFS	Tertile	All	0.660	0.538	.003	23	view →
HNSC	DFS	Quartile	IV	0.642	0.222	<.001	16	view →
CHOL	OS	Median	III,IV	0.136	0.859	.003	15	view →
CESC	OS	Tertile	All	0.632	0.435	.010	14	view →
COAD	DFS	Median	All	0.368	0.697	.010	14	view →
LUSC	OS	Median	All	0.808	0.713	.019	10	view →
STAD	DFS	Median	IV	0.321	0.458	.010	9	view →
MESO	OS	Quartile	III,IV	0.842	0.309	.017	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

PTH2R–UVM (DFS)

Open the UVM breakdown →