PTH2R

Across TCGA cell cohorts, PTH2R RNA expression is significantly associated with the go_rna of many other GO terms, with 2,418 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PTH2R-associated GO terms across cancer lineages are Sodium ion transport, Lysosome to ER cholesterol transport, and Positive regulation of reproductive process. Each is linked with PTH2R in more than 4 cancer types. Because this analysis shows association rather than direction, both PTH2R-to-partner and partner-to-PTH2R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Sodium ion transport grouped by PTH2R-low versus PTH2R-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTH2R→partner) and Y-score (partner→PTH2R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Sodium ion transport →	-0.050	-0.368	<.001	.009	3	5
STOMACH	Lysosome to ER cholesterol transport →	+0.124	+0.648	.001	.004	3	5
KIDNEY	Positive regulation of reproductive process →	-0.055	-1.292	.003	.004	3	5
BLOOD_Leukemia	Regulation of nervous system process →	-0.028	-1.028	.001	.003	3	5
BLOOD_Leukemia	Protein localization to vacuole →	+0.038	+1.076	<.001	<.001	3	5
LARGE_INTESTINE	Negative regulation of T cell mediated immunity →	-0.110	-0.543	.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,418 associations by consensus.

Sodium ion transport by PTH2R expression — LARGE_INTESTINE

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