PTH2R

Across TCGA cell cohorts, PTH2R mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTH2R-associated genes across cancer lineages are DNAJC5B, GCSAML, and PDILT. Each is linked with PTH2R in more than 1 cancer types. Because this analysis shows association rather than direction, both PTH2R-to-partner and partner-to-PTH2R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNAJC5B grouped by PTH2R-low versus PTH2R-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTH2R→partner) and Y-score (partner→PTH2R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DNAJC5B →	+0.140	+2.878	.005	.009	3	1
LARGE_INTESTINE	GCSAML →	+0.030	+3.426	<.001	.007	3	1
LARGE_INTESTINE	PDILT →	+0.005	+3.700	<.001	.009	3	1
LARGE_INTESTINE	ZNF683 →	+0.007	+3.562	.004	.002	3	1
LARGE_INTESTINE	ST8SIA3 →	+0.027	+3.242	.001	.003	3	1
LARGE_INTESTINE	HNRNPCL4 →	+0.063	+3.115	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

DNAJC5B by PTH2R expression — LARGE_INTESTINE

Explore this box plot interactively →