PTH1R

Across TCGA patient cohorts, PTH1R mutation is significantly associated with the RNA expression of many other genes, with 5,445 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTH1R-associated genes across cancer lineages are PRMT1, MVD, and COQ2. Each is linked with PTH1R in more than 2 cancer types. Because this analysis shows association rather than direction, both PTH1R-to-partner and partner-to-PTH1R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRMT1 grouped by PTH1R-low versus PTH1R-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTH1R→partner) and Y-score (partner→PTH1R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRMT1 →	+0.397	+2.447	.009	.001	3	3
UCEC	MVD →	+0.704	+2.906	<.001	<.001	3	3
UCEC	COQ2 →	+0.425	+2.010	.003	.001	3	3
UCEC	COX5A →	+0.332	+3.595	.007	.001	3	2
UCEC	MRFAP1 →	+0.459	+2.914	.001	.001	3	2
UCEC	EDC3 →	+0.343	+2.413	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,445 associations by consensus.

PRMT1 by PTH1R expression — UCEC

Explore this box plot interactively →