PTH1R

Across TCGA pan-cancer cohorts, PTH1R RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of PTH1R’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PTH1R RNA is repressed in tumor relative to normal tissue. In most cancer types PTH1R is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and KIRP are the cancer types where PTH1R tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PTH1R RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	IV	−3.229	<.001	12	view →
KICH	Male	II,III,IV	−6.126	<.001	11	view →
KIRP	Male	III,IV	−3.482	<.001	11	view →
BLCA	Male	IV	−2.795	<.001	11	view →
LUAD	Female	III,IV	−1.994	<.001	11	view →
COAD	Female	II,III,IV	−0.984	<.001	10	view →
LIHC	Male	III,IV	−2.716	<.001	9	view →
UCEC	All	III,IV	−2.752	<.001	8	view →
LUSC	Female	All	−2.231	<.001	7	view →
BRCA	All	II,III,IV	−1.734	<.001	6	view →
STAD	Female	All	−1.372	<.001	6	view →
CHOL	Male	All	−2.356	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

PTH1R–KIRC

Open the KIRC breakdown →