PTGER4

Across TCGA patient cohorts, PTGER4 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTGER4-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and eIF4E. Each is linked with PTGER4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTGER4-to-partner and partner-to-PTGER4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by PTGER4-low versus PTGER4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTGER4→partner) and Y-score (partner→PTGER4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.068	-2.088	.035	.016	3	1
UCEC	EGFR_pY1068 →	-0.286	-2.378	<.001	<.001	3	1
UCEC	eIF4E →	+0.179	+3.713	.007	<.001	3	1
UCEC	A-Raf_pS299 →	-0.131	-2.584	<.001	.001	3	1
UCEC	ERK2 →	+0.181	+2.700	.003	.005	3	1
UCEC	FOXO3a_pS318_S321 →	-0.101	-1.523	.011	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

14-3-3_beta by PTGER4 expression — UCEC

Explore this box plot interactively →