PTGER4

Across TCGA pan-cancer cohorts, PTGER4 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PTGER4’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PTGER4 RNA is repressed in tumor relative to normal tissue. In most cancer types PTGER4 is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

COAD, LUAD, and KIRC are the cancer types where PTGER4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PTGER4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	−2.154	<.001	11	view →
LUAD	Female	III,IV	−1.880	<.001	11	view →
KIRC	Female	IV	−1.638	<.001	11	view →
KICH	Male	II,III,IV	−2.637	<.001	10	view →
KIRP	Female	II,III,IV	−2.106	<.001	9	view →
LUSC	All	II,III,IV	−1.412	<.001	8	view →
BLCA	All	All	−1.296	.003	7	view →
BRCA	All	III,IV	−1.494	<.001	6	view →
UCEC	All	All	−1.415	<.001	6	view →
READ	All	All	−1.688	.003	3	view →
THCA	Female	All	−0.649	.004	2	view →
CHOL	All	All	+0.881	.016	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PTGER4–COAD

Open the COAD breakdown →