PTGER4

Across TCGA pan-cancer cohorts, PTGER4 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated PTGER4 data layer compared with 3 for mutation status.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher PTGER4 RNA is associated with better overall survival. In most high-consensus cancer types, elevated PTGER4 expression acts as an unfavorable survival marker, although some lineages such as SKCM and BLCA show a favorable association.

SKCM, UVM, and LGG are the cancer types where PTGER4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.406	0.269	<.001	113	view →
UVM	DFS	Tertile	All	0.313	0.768	.003	55	view →
LGG	OS	Median	All	0.372	0.511	<.001	51	view →
BLCA	DFS	Median	II,III,IV	0.395	0.286	.013	40	view →
KICH	OS	Tertile	II,III,IV	0.645	1.000	.008	37	view →
BRCA	OS	Median	III,IV	0.894	0.757	.001	32	view →
KIRC	DFS	Tertile	All	0.749	0.517	.007	28	view →
CHOL	DFS	Tertile	All	0.625	0.152	.011	23	view →
HNSC	DFS	Quartile	III,IV	0.519	0.277	.012	23	view →
PCPG	DFS	Median	All	0.972	0.861	.008	15	view →
LUSC	OS	Median	IV	0.255	0.851	.021	14	view →
ESCA	DFS	Median	All	0.598	0.409	.005	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

PTGER4–SKCM (OS)

Open the SKCM breakdown →