PTGER4

Across TCGA cell cohorts, PTGER4 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible PTGER4-associated genes across cancer lineages are BMP15, CDRT15L2, and VCY1B. Each is linked with PTGER4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTGER4-to-partner and partner-to-PTGER4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BMP15 grouped by PTGER4-low versus PTGER4-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTGER4→partner) and Y-score (partner→PTGER4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	BMP15 →	+0.016	+5.781	<.001	.001	3	1
BREAST	CDRT15L2 →	+0.013	+5.781	<.001	.001	3	1
OVARY	VCY1B →	+0.305	+4.029	<.001	.009	3	1
OVARY	MTNR1B →	+0.231	+4.029	<.001	.009	3	1
OVARY	CT47B1 →	+0.027	+4.450	<.001	.004	3	1
LARGE_INTESTINE	LYPD4 →	+0.051	+3.920	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

BMP15 by PTGER4 expression — BREAST

Explore this box plot interactively →