PTGER3

Across TCGA cell cohorts, PTGER3 mutation is significantly associated with the RNA expression of many other genes, with 39 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTGER3-associated genes across cancer lineages are IDI2, OR2AK2, and OR10C1. Each is linked with PTGER3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTGER3-to-partner and partner-to-PTGER3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IDI2 grouped by PTGER3-low versus PTGER3-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTGER3→partner) and Y-score (partner→PTGER3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	IDI2 →	+0.033	+3.977	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR2AK2 →	+0.029	+3.947	<.001	.004	3	1
LUNG_NSCLC_LUAD	OR10C1 →	+0.040	+4.681	<.001	.003	3	1
OVARY	KRT73 →	+0.016	+5.196	<.001	.005	3	1
LARGE_INTESTINE	VHL →	+0.754	+3.067	.002	.009	3	1
LARGE_INTESTINE	ACOT12 →	+0.023	+3.479	.009	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

IDI2 by PTGER3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →