PTGDS

Across TCGA patient cohorts, PTGDS mutation is significantly associated with the RNA expression of many other genes, with 940 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTGDS-associated genes across cancer lineages are PIGPP3, LINC02590, and OR51H1. Each is linked with PTGDS in more than 2 cancer types. Because this analysis shows association rather than direction, both PTGDS-to-partner and partner-to-PTGDS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PIGPP3 grouped by PTGDS-low versus PTGDS-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTGDS→partner) and Y-score (partner→PTGDS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PIGPP3 →	+0.144	+5.736	<.001	.003	3	3
UCEC	LINC02590 →	+0.135	+2.673	<.001	.003	3	3
HNSC	OR51H1 →	+0.070	+5.736	<.001	.003	3	2
HNSC	RNU6-396P →	+0.456	+5.124	<.001	.008	3	2
HNSC	KRTAP6-3 →	+0.093	+5.069	.003	.008	3	2
HNSC	MRPL49P1 →	+0.112	+5.368	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 940 associations by consensus.

PIGPP3 by PTGDS expression — HNSC

Explore this box plot interactively →