PTGDS

Across TCGA pan-cancer cohorts, PTGDS RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PTGDS’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where PTGDS RNA is repressed in tumor relative to normal tissue. In most cancer types PTGDS is over-expressed in tumor, although a few such as KIRP and BLCA show the opposite, repressed pattern.

KIRP, BLCA, and LUSC are the cancer types where PTGDS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PTGDS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Female	II,III,IV	−4.478	<.001	11	view →
BLCA	Female	All	−3.132	<.001	11	view →
LUSC	Male	II,III,IV	−3.660	<.001	9	view →
LUAD	Male	All	−2.270	<.001	9	view →
KIRC	Male	All	−2.168	<.001	9	view →
COAD	All	All	−1.096	<.001	9	view →
UCEC	All	III,IV	−3.866	<.001	8	view →
HNSC	Male	All	−1.673	<.001	8	view →
KICH	Female	All	−5.152	<.001	7	view →
BRCA	All	II,III,IV	−2.065	<.001	6	view →
THCA	Female	All	−1.573	<.001	5	view →
PRAD	All	All	−1.498	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PTGDS–KIRP

Open the KIRP breakdown →