PTGDS

Across TCGA pan-cancer cohorts, PTGDS RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated PTGDS data layer compared with 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PTGDS RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated PTGDS expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, LUAD, and ESCA are the cancer types where PTGDS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.409	0.248	<.001	132	view →
LUAD	DFS	Tertile	All	0.873	0.744	<.001	74	view →
ESCA	DFS	Median	All	0.599	0.396	.002	56	view →
UCEC	DFS	Tertile	All	0.881	0.777	.002	52	view →
KIRC	OS	Median	All	0.576	0.677	.009	32	view →
CESC	OS	Quartile	All	0.894	0.705	.001	32	view →
UCS	DFS	Quartile	II,III,IV	0.146	0.540	.002	28	view →
DLBC	DFS	Tertile	All	0.931	0.450	.011	28	view →
OV	OS	Tertile	III,IV	0.789	0.876	.009	26	view →
LUSC	OS	Tertile	All	0.687	0.800	.009	24	view →
THCA	DFS	Quartile	IV	1.000	0.524	.007	19	view →
SKCM	DFS	Quartile	IV	0.842	0.182	.011	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

PTGDS–HNSC (DFS)

Open the HNSC breakdown →