PTGDS

Across TCGA cell cohorts, PTGDS RNA expression is significantly associated with the go_rna of many other GO terms, with 1,271 significant associations in total. CNS shows the largest number of these associations.

The most reproducible PTGDS-associated GO terms across cancer lineages are Regulation of amyloid precursor protein catabolic process, Phospholipid efflux, and Oligosaccharide metabolic process. Each is linked with PTGDS in more than 7 cancer types. Because this analysis shows association rather than direction, both PTGDS-to-partner and partner-to-PTGDS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of amyloid precursor protein catabolic process grouped by PTGDS-low versus PTGDS-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTGDS→partner) and Y-score (partner→PTGDS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of amyloid precursor protein catabolic process →	+0.082	+1.154	.009	.007	3	8
BLOOD_Leukemia	Phospholipid efflux →	+0.211	+1.381	<.001	.003	3	6
CNS	Oligosaccharide metabolic process →	+0.080	+1.394	.001	.002	3	6
OESOPHAGUS	Lipid modification →	+0.061	+1.270	<.001	.007	2	7
OVARY	Regulation of amyloid-beta formation →	+0.064	+2.262	<.001	<.001	3	6
OVARY	Lipid oxidation →	+0.070	+2.342	.001	.003	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,271 associations by consensus.

Regulation of amyloid precursor protein catabolic process by PTGDS expression — OESOPHAGUS

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