PTGDR

Across TCGA patient cohorts, PTGDR mutation is significantly associated with the RNA expression of many other genes, with 3,571 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTGDR-associated genes across cancer lineages are RNU1-17P, RNU6-1156P, and RN7SKP177. Each is linked with PTGDR in more than 1 cancer types. Because this analysis shows association rather than direction, both PTGDR-to-partner and partner-to-PTGDR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-17P grouped by PTGDR-low versus PTGDR-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTGDR→partner) and Y-score (partner→PTGDR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU1-17P →	+0.235	+3.688	<.001	.004	3	2
CESC	RNU6-1156P →	+0.324	+2.982	.001	.009	3	2
CESC	RN7SKP177 →	+0.061	+4.020	.003	.009	3	2
LUAD	MIR4733 →	+0.462	+3.906	.004	<.001	3	2
COAD	POLR3KP2 →	+0.354	+6.003	<.001	.002	3	2
BRCA	RNU6-973P →	+0.810	+3.751	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,571 associations by consensus.

RNU1-17P by PTGDR expression — CESC

Explore this box plot interactively →