PTGDR

Across TCGA pan-cancer cohorts, PTGDR RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PTGDR’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PTGDR RNA is repressed in tumor relative to normal tissue. In most cancer types PTGDR is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

COAD, KIRC, and THCA are the cancer types where PTGDR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PTGDR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−2.744	<.001	12	view →
KIRC	Male	All	+0.753	<.001	11	view →
THCA	Female	II,III,IV	−0.570	<.001	11	view →
HNSC	Female	II,III,IV	+0.458	<.001	11	view →
LUSC	Female	All	−0.905	<.001	7	view →
UCEC	All	All	−0.926	<.001	6	view →
LUAD	Female	III,IV	−0.804	<.001	6	view →
BRCA	All	III,IV	−0.625	<.001	6	view →
BLCA	Male	IV	−0.542	.024	6	view →
READ	All	All	−2.371	<.001	5	view →
CHOL	All	II,III,IV	−0.660	.020	2	view →
KICH	All	All	−0.265	.021	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PTGDR–COAD

Open the COAD breakdown →