PTGDR

Across TCGA patient cohorts, PTGDR mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTGDR-associated genes across cancer lineages are Shc_pY317, TFRC, and Tuberin. Each is linked with PTGDR in more than 1 cancer types. Because this analysis shows association rather than direction, both PTGDR-to-partner and partner-to-PTGDR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by PTGDR-low versus PTGDR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTGDR→partner) and Y-score (partner→PTGDR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.137	-1.440	.009	.024	3	2
UCEC	TFRC →	+0.481	+2.000	.008	.029	3	2
UCEC	Tuberin →	+0.338	+2.179	<.001	.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.723	+2.807	<.001	.002	3	2
UCEC	Caspase-8 →	-0.243	-3.143	.005	<.001	3	2
UCEC	EGFR_pY1068 →	-0.249	-1.736	.004	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Shc_pY317 by PTGDR expression — UCEC

Explore this box plot interactively →