PTGDR

Across TCGA cell cohorts, PTGDR mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PTGDR-associated genes across cancer lineages are CST9L, IFNA8, and ADGRE3. Each is linked with PTGDR in more than 1 cancer types. Because this analysis shows association rather than direction, both PTGDR-to-partner and partner-to-PTGDR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CST9L grouped by PTGDR-low versus PTGDR-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTGDR→partner) and Y-score (partner→PTGDR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CST9L →	+0.028	+5.369	<.001	.004	3	1
SOFT_TISSUE	IFNA8 →	+0.038	+4.930	<.001	.008	3	1
SOFT_TISSUE	ADGRE3 →	+0.006	+5.977	<.001	.001	3	1
SOFT_TISSUE	LYZL2 →	+0.036	+5.977	<.001	.001	3	1
SOFT_TISSUE	KRT6C →	+0.013	+4.930	<.001	.008	3	1
SOFT_TISSUE	RLN3 →	+0.059	+5.369	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

CST9L by PTGDR expression — SOFT_TISSUE

Explore this box plot interactively →